The artists collection is made up of two segments: international and national.

The international segment of the collections reflects the modern art from almost all parts of the world. The bigger part of the collection marks the art movements of the 1950's, 1960's and 1970's, although it contains also around a hundred works of the early modern art. The older exhibits are mainly marked by works of Emil Filla, František Muzika, Fernand Léger, André Masson, etc. The works of the internationally well-known artists are of special importance, such as: Pablo Picasso, Hans Hartung, Victor Vasarely, Alexander Calder, Pierre Soulages, Henryk Staževski, Alberto Burri, Christo, Enrico Bay, Robert Jacobsen, Etienne Hajdu, Zoltan Kemeny, Robert Adams, Emilio Vedova, Antoni Clavé, Georg Baselitz...

The national collection of the Museum enables to follow the development of the fine art in Macedonia with all its specific features, starting from the middle of the 20th century with the appearance of the first generation of contemporary artists - the founders of Macedonian modern art: Dimitar Pandilov, Lazar Licenoski, Nikola Martinoski, Dimo Todorovski, all the way to the generations that have appeared after WW 2: Dimitar Kondovski, Risto Lozanoski, Petar Mazev, Dušan Percinkov, Rodoljub Anastasov, Tanas Lulovski, Jordan Grabuloski, Aneta Svetieva, Dimitar Manev, Gligor Stefanov, Petre Nikoloski, Blagoja Maneski, Jovan Šumkovski, etc.